Registro de síndrome coronariana aguda na enfermaria do Hospital Governador Flávio Ribeiro Coutinho em Santa Rita-PB / Record of Acute Coronary Syndrome in the infirmary at Governador Hospital Flávio Ribeiro Coutinho in Santa Rita-PB

Observamos que no nosso serviço, o uso de AAS e clopidogrel na emergência, a positividade da CKMB e um maior período de internamento estiveram associados a uma maior associação com pontuação intermediária no escore de risco TIMI

The Role of Isotretinoin Therapy for Cushing's Disease: Results of a Prospective Study.

Objective. This prospective open trial aimed to evaluate the efficacy and safety of isotretinoin (13-cis-retinoic acid) in patients with Cushing's disease (CD). Methods. Sixteen patients with CD and persistent or recurrent hypercortisolism after transsphenoidal surgery were given isotretinoin orally for 6-12 months. The drug was started on 20 mg daily and the dosage was increased up to 80 mg daily if needed and tolerated. Clinical, biochemical, and hormonal parameters were evaluated at baseline and monthly for 6-12 months. Results. Of the 16 subjects, 4% (25%) persisted with normal urinary free cortisol (UFC) levels at the end of the study. UFC reductions of up to 52.1% were found in the rest. Only patients with UFC levels below 2.5-fold of the upper limit of normal achieved sustained UFC normalization. Improvements of clinical and biochemical parameters were also noted mostly in responsive patients. Typical isotretinoin side-effects were experienced by 7 patients (43.7%), though they were mild and mostly transient. We also observed that the combination of isotretinoin with cabergoline, in relatively low doses, may occasionally be more effective than either drug alone. Conclusions. Isotretinoin may be an effective and safe therapy for some CD patients, particularly those with mild hypercortisolism.

Prescrições geriátricas inapropriadas e polifarmacoterapia em enfermarias de clínica médica de um Hospital-Escola / Inappropriate geriatric prescriptions and poly-pharmacotherapy in medical clinic wards at a University Hospital

OBJETIVOS: Avaliar a prevalência do uso de prescrições potencialmente inapropriadas (PPI) e polifarmacoterapia na clientela idosa hospitalizada nas enfermarias de clínica médica do Hospital Universitário Lauro Wanderley (HULW), Universidade Federal da Paraíba. METODOLOGIA: Estudo observacional e transversal com análise das prescrições geriátricas realizadas por médicos residentes em clínica médica no HULW. A amostra foi composta pela totalidade dos pacientes idosos internados nas enfermarias do HULW entre maio de 2007 e maio de 2008. Para identificar PPI, foram adotados os Critérios de Beers-Fick. Definiu-se polifarmacoterapia como o uso de mais de cinco medicamentos por prescrição. RESULTADOS: Avaliaram-se as prescrições de 79 pacientes de 60 a 94 anos (70,4 +/- 7,3), 59,5% do sexo masculino. O número de medicamentos usados variou de 2 a 12 (6,1+/-2,0) por paciente. As classes terapêuticas mais prescritas foram as relacionadas aos aparelhos digestório (83,6%), cardiovascular (63,9%) e nervoso (49,2%). Os princípios ativos mais prescritos foram metoclopramida, ranitidina, dipirona e captopril. A maioria dos pacientes, 36 (59%), apresentou polifarmacoterapia. Mais da metade dos pacientes (54,1%,) recebeu pelo menos uma prescrição inapropriada, com maior frequência de nifedipina, butilescopolamina e diazepam. CONCLUSÕES: Identificaram-se, além de uma alta prevalência de PPI e polifarmacoterapia, excesso de prescrições de antiulcerosos e antieméticos na amostra estudada. Estes resultados indicam que maior atenção deve ser dada à prescrição para pacientes idosos. A difusão do conceito de uso inapropriado para pacientes idosos mediante educação continuada para médicos residentes poderia facilitar a adoção dos critérios de Beers-Fick, ainda não conhecidos por toda a comunidade médica.

OBJECTIVES: To assess the prevalence of Potentially Inappropriate Prescribing (PIP) and many different drugs in hospitalized elderly client in the infirmary of medical clinic, Lauro Wanderley University Hospital (LWUH), Federal University of Paraíba. METHODOLOGY: Observational and cross-sectional analysis of prescriptions geriatric performed by resident physicians in internal medicine at LWUH. The sample was composed of all elderly patients hospitalized in the LWUH between May 2007 and May 2008. The Beers-Fick criteria were used to identify PIP. Poly-pharmacotherapy was defined as the use of more than five drugs per prescription. RESULTS: We evaluated 79 patients aged 60 to 94 years (70.4 + / - 7.3), 59.5% were male. The number of medications used ranged from 2 to 12 (6.1 + / -2.0) per patient. The most prescribed therapeutic classes were due to digestive (83.6%), cardiovascular (63.9%) and nervous (49.2%). The most frequently prescribed were metoclopramide, ranitidine, dipyrone and captopril. Most patients, 36 (59%), had many different drugs. More than half of patients (54.1%) received at least one inappropriate prescription, with a higher frequency of nifedipine, scopolamine and diazepam. CONCLUSIONS: We identified, in addition to a high prevalence of PIP and many different drugs, over-prescription anti-ulcer and anti-emetics in the sample. These results indicate that more attention should be given to prescribing for elderly patients. The diffusion of the concept of PIP for elderly patients through continuing education for medical residents could help the adoption of the Beers-Fick criteria, not yet known throughout the medical community.

Effectiveness of adding vildagliptin to the treatment of diabetic patients nonresponsive to the combination of metformin and a sulphonylurea.

OBJECTIVE: To evaluate the effectiveness of adding vildagliptin to the treatment of patients with inadequately controlled type 2 diabetes mellitus (T2DM) treated with a combination of metformin and a sulphonylurea. SUBJECTS AND METHODS: 37 T2DM patients with HbA1c ranging from 7.7% to 12.4% (mean of 9.30 ± 1.38), despite the use of metformin in combination with a sulphonylurea, were additionally treated with vildagliptin (100 mg/day) for at least 6 months. RESULTS: During triple oral therapy (TOT) HbA1c levels < 7% were achieved in 11 patients (29.7%), whereas levels of fasting plasma glucose (FPG) < 120 mg/dL were observed in 12 patients (32.4%). Both findings were observed in 10 patients (27.0%). Compared to nonresponsive subjects, lower mean baseline HbA1c and FPG levels were seen in responsive patients, but the difference was only statistically significant for fasting plasma glucose (FPG). Moreover, there was considerable overlap between the two groups. CONCLUSION: Our preliminary results suggest that TOT with metformin, a sulphonylurea and vildagliptin may be useful for some T2DM patients nonresponsive to combination therapy with metformin and sulphonylurea.

Effectiveness of adding vildagliptin to the treatment of diabetic patients nonresponsive to the combination of metformin and a sulphonylurea / Eficácia da adição de vildagliptina ao tratamento de pacientes diabéticos não responsivos à combinação de metformina e uma sulfonilureia

OBJECTIVE: To evaluate the effectiveness of adding vildagliptin to the treatment of patients with inadequately controlled type 2 diabetes mellitus (T2DM) treated with a combination of metformin and a sulphonylurea. SUBJECTS AND METHODS: 37 T2DM patients with HbA1c ranging from 7.7 percent to 12.4 percent (mean of 9.30 ± 1.38), despite the use of metformin in combination with a sulphonylurea, were additionally treated with vildagliptin (100 mg/day) for at least 6 months. RESULTS: During triple oral therapy (TOT) HbA1c levels < 7 percent were achieved in 11 patients (29.7 percent), whereas levels of fasting plasma glucose (FPG) < 120 mg/dL were observed in 12 patients (32.4 percent). Both findings were observed in 10 patients (27.0 percent). Compared to nonresponsive subjects, lower mean baseline HbA1c and FPG levels were seen in responsive patients, but the difference was only statistically significant for fasting plasma glucose (FPG). Moreover, there was considerable overlap between the two groups. CONLUSION: Our preliminary results suggest that TOT with metformin, a sulphonylurea and vildagliptin may be useful for some T2DM patients nonresponsive to combination therapy with metformin and sulphonylurea.

OBJETIVO: Avaliar a eficácia da adição de vildagliptina ao tratamento de pacientes com diabetes melito tipo 2 (DM2) inadequadamente controlados com a terapia de combinação com metformina e sulfonilureia. SUJEITOS E MÉTODOS: 37 pacientes com DM2 e HbA1c variando entre 7,7 por cento e 12,4 por cento (média, 9,30 ± 1,38), apesar do uso de metformina associada a uma sulfonilureia, foram adicionalmente tratados com vildagliptina (100 mg/dia) durante, pelo menos, 6 meses. RESULTADOS: Durante a terapia oral tripla TOT), níveis de HbA1c < 7 por cento foram alcançados em 11 pacientes (27,9 por cento), enquanto a glicemia de jejum (GJ) < 120 mg/dL foi observada em 12 pacientes (32,4.1 por cento). Ambos os resultados foram descritos em 10 pacientes (27,0 por cento). Em comparação com indivíduos não responsivos, os pacientes responsivos tinham níveis basais mais baixos de HbA1c e GJ, mas a diferença foi estatisticamente significativa somente para glicemia de jejum. Além disso, houve grande sobre-posição entre os dois grupos. CONSLUSÃO: Nossos resultados preliminares sugerem que a TOT com metformina, uma sulfonilureia e vildagliptina pode ser útil para alguns pacientes com DM2 não responsivos à combinação com metformina e uma sulfonilureia.